SSR 69071
- Product Name
- SSR 69071
- CAS No.
- 344930-95-6
- Chemical Name
- SSR 69071
- Synonyms
- SSR 69071;2-[[6-Methoxy-4-(1-methylethyl)-1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl]methoxy]-9-[2-(1-piperidinyl)ethoxy]-4H-pyrido[1,2-a]pyrimidin-4-one;4H-Pyrido[1,2-a]pyrimidin-4-one, 2-[[6-methoxy-4-(1-methylethyl)-1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl]methoxy]-9-[2-(1-piperidinyl)ethoxy]-
- CBNumber
- CB6838847
- Molecular Formula
- C27H32N4O7S
- Formula Weight
- 556.63
- MOL File
- 344930-95-6.mol
SSR 69071 Property
- storage temp.
- Store at +4°C
- solubility
- Soluble in DMSO
- form
- solid
- color
- Off-white
N-Bromosuccinimide Price
- Product number
- 21477
- Product name
- SSR 69071
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 21477
- Product name
- SSR 69071
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $122
- Updated
- 2024/03/01
- Product number
- 21477
- Product name
- SSR 69071
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $230
- Updated
- 2024/03/01
- Product number
- 2506
- Product name
- SSR69071
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $242
- Updated
- 2021/12/16
- Product number
- 256757
- Product name
- SSR 69071
- Packaging
- 10mg
- Price
- $489
- Updated
- 2021/12/16
SSR 69071 Chemical Properties,Usage,Production
Description
SSR 69071 is a potent inhibitor of neutrophil elastase (Ki = 0.0168 nM for the human enzyme). It is selective for human neutrophil elastase over rat, mouse, and rabbit elastases (Kis = 3, 1.8, 58 nM, respectively). It inhibits human neutrophil elastase ex vivo in mouse bronchoalveolar lavage (BAL) fluid (ED50 = 10.5 mg/kg, p.o.). In vivo, SSR 69071 (2.8 mg/kg, p.o.) reduces acute lung hemorrhage induced by human neutrophil elastase in mice. It reduces carrageenan- and human neutrophil elastase-induced paw edema in rats (ED30s = 2.2 and 2.7 mg/kg, respectively). SSR 69071 also reduces cardiac infarct size when administered prior to ischemia or reperfusion in a rabbit model of ischemia-reperfusion injury.
Uses
SSR 69071 is a novel and orally active elastase inhibitor.
Definition
ChEBI: 6-methoxy-1,1-dioxo-2-[[4-oxo-9-[2-(1-piperidinyl)ethoxy]-2-pyrido[1,2-a]pyrimidinyl]oxymethyl]-4-propan-2-yl-1,2-benzothiazol-3-one is a pyridopyrimidine.
Biological Activity
Orally active, high affinity and potent inhibitor of human leukocyte elastase (HLE) (IC 50 = 3.9 nM). Displays species-selectivity (K i values are 0.017, 1.70, 3.01, 58 and > 100 nM? for human, mouse, rat, rabbit and porcine elastase respectively). In vivo, inhibits HLE-induced lung hemorrhage in mice (ID 50 = 2.8 mg/kg) and reduces infarct size in an acute model of coronary ischemia-reperfusion injury.
storage
Store at +4°C